Research

Clinical studies

Pulmonary Arterial Hypertension

Some patients with congenital heart defects suffer from a particular kind of pulmonary hypertension known as pulmonary arterial hypertension (PAH). The Competence Network has investigated new forms of drug therapy for treating PAH. read more …

Tetralogy of Fallot

Tetralogy of Fallot is the most common cyanotic heart defect. The Competence Network’s studies investigated the long-term prognosis of the disease after surgical correction. The main emphasis lies on methods to determine the diminution of right ventricular function. read more …

Right heart failure

Little is currently known about the efficacy of beta blockers in the treatment of right ventricular failure. This multistage drug-based intervention study conducts tests to determine whether this type of drug is capable of improving right ventricular function. read more …

Heart rhythm disorders

This multi-centric, prospective, therapy study investigates the effects of cardiac resynchronisation therapy on right and left ventricular function in patients with congenital heart defects. read more …

Duchenne muscular dystrophy

Goal of this study is to find out whether a preventive therapy can serve to delay the start of a cardiac insufficiency and thereby lead to an improved quality of life as well as to a prolonged survival rate in patients with a known Duchenne muscular dystrophy. read more …

Pulmonary stenosis

A study on the diagnostics and therapy of peripheral pulmonary stenoses serves as a basis for developing diagnosis guidelines and new forms of treatment for this illness. The aim is to treat right ventricular dysfunction due to pulmonary obstructions in good time, using surgical or alternatively interventional methods. read more …

Objective exercise tolerance

Physical capacity has an immediate impact on the everyday lives of patients with congenital heart defects. This study establishes criteria for assessing the exercise tolerance of affected children and adolescents on the basis of standardised examination parameters. read more …

Magnetic resonance imaging (MRI)

The magnetic resonance imaging study for the first time provides quantitative measurements of highly differentiated parameters of right ventricle function. read more …

Echocardiography

Tissue Doppler echocardiography is a rapid, non-invasive means of assessing myocardial function and obtaining global information on right ventricular function. For the first time, these data are being evaluated on a broad clinical basis in the competence network study and used to assess therapeutic outcome. read more …

Quality of life

The ultimate aim of medical treatment must necessarily be to improve the quality of patients’ lives. All studies carried out by the competence network include gathering data on quality of life using generic questionnaires to obtain subjective viewpoints on health-related quality of life. read more …

Guidelines

Evidence-based guidelines greatly help to improve prevention, diagnostics, and therapy in clinical care. This is why the Competence Network works with its partners to develop guidelines, recommendations, and reference values for the treatment of congenital heart defects. read more …